FCRL3 and hypothyroidism: Nonetheless, in another study, FCRL3 expression levels in HT were observed to be increased in hypothyroid patients [18], but L-thyroxine replacement did not seem to offset the increase in FCRL3 expression; thus, authors hypothesized that the thyroid immune injury, rather than biochemical hypothyroidism, has been associated with altered FCRL3 expression in HT [18].