Similarly, significant interactions were found between the grade of periodontitis and treatment effects for PD, CAL, MDA, TAC, and SOD (p < 0.05), with greater improvements observed in the test group compared with the control group in grades B and C. These findings suggest that the efficacy of the interventions was more pronounced in patients with advanced stages and higher grades of periodontitis. Here, SOD1 is linked to periodontitis.