CD274 and neoplasm: However, in our series, strictly based on homogenous criteria, the most prevalent subset (23/36) was that in which cancer preceded sarcoidosis (63.9%); sarcoidosis developed after the diagnosis of a tumor or in conjunction with it, emphasizing the difference between “true” sarcoidosis and SLRs, a secondary event triggered by neoplastic proliferation [41,76,77] or in response to chemotherapeutic agents that increased immunoreactivity, such as interferon or PDL1 inhibitors [78,79,80] to counteract neoplastic proliferation.