IL-23 bridges the innate and adaptive immune systems: it acts on T cells as well as innate immune cells (e.g., natural killer cells, macrophages, dendritic cells, and innate lymphoid cells), normally confers immunity against bacterial and fungal infections, and it is pivotal in maintaining and expanding Th17 cells, which produce pro-inflammatory cytokines such as IL-17A, IL-17F, and tumor necrosis factor (TNF) [5,6]. This evidence concerns the gene TNF and fungal infectious disease.