This study found a slight decrease in high-molecular-weight vWF multimers and a relative increase of intermediate/low-molecular-weight vWF multimers, which was more pronounced in the most severe cases of COVID-19 infection; authors proposed that this may be explained by an early increase of vWF proteolysis by ADAMTS13, as it attempts to overcome the excess release of vWF in response to local hyperinflammation and endothelial activation in COVID-19. This evidence concerns the gene VWF and COVID-19.