Ocak et al. showed an increased mortality in 956 dialysis patients with higher levels of vWF and reduced ADAMTS13 activity; specifically, those dialysis patients in the highest quartile of vWF had a 1.4-fold (95% CI 1.1–1.8) increased mortality risk compared with those in the lowest quartile for vWF, even after adjustment for other risk factors including age, sex, body mass index, cardiovascular disease, smoking, type of dialysis, primary kidney disease, use of antithrombotic medication, blood pressure, albumin levels, CRP levels and baseline eGFR [37]. This evidence concerns the gene VWF and cardiovascular disorder.