Unlike in ischaemic stroke, moderately low ADAMTS13 levels were not associated with an increased risk of myocardial infarction (lowest quartile vs. highest quartile, OR 1.28 [95% CI 0.68–2.45]), and there was no trend observed in the intermediate quartiles, with the authors suggesting a clinically relevant “threshold” for ADAMTS13 activity and increased myocardial ischaemia risk rather than a dose-dependent relationship [32]. This evidence concerns the gene ADAMTS13 and ischemic stroke.