According to ELN guidelines, real-time quantitative PCR (RT-PCR) is recommended as the gold standard for AML cases exhibiting specific abnormalities like PML-RARA, RUNX1-RUNX1T1, CBFB-MYH11, or NPM1, encompassing 40% of AML patients [10]. Here, RUNX1 is linked to acute myeloid leukemia.