The limitations of this study include the following: inclusion of only singleton data from ART pregnancies; the absence of data on placental abruption, neonatal respiratory distress syndrome, and/or pregnancy loss among adverse pregnancy outcomes; the absence of data on the prognosis of the child, such as respiratory disorders and cognitive function; and the absence of data on anti-TPO antibodies. The gene discussed is TPO; the disease is placental abruption.