TGM2 and irritable bowel syndrome: Therefore, it is necessary to conduct the following diagnostic tests in all individuals who are suspected to have IBS: full blood count, inflammatory markers such as C-reactive protein and erythrocyte sedimentation rate, IgA anti-tissue transglutaminase antibodies and total IgA, thyroid-stimulating hormone (TSH), and in patients with diarrhea, fecal calprotectine [23,24].