APOB and obesity due to melanocortin 4 receptor deficiency: These observations are consistent with scientific evidence, where it has repeatedly been shown that patients with obesity-related diseases are characterized by abnormal lipidograms, especially high levels of triglycerides, non-HDL and apolipoprotein B. It is estimated that this problem can affect up to 60–70% of patients with obesity and 50–60% of overweight patients.