The FVIII IVR of rFVIIIFc by OSA was quite good, 2.12 ± 0.52 dL/kg, being the Cmax 101.05 ± 25.65 IU/dL, like the mean value (2.20 dL/kg) reported in the rFVIIIFc PK multicenter study conducted in France [18]. The gene discussed is F8; the disease is obstructive sleep apnea syndrome.