Thus, the primary objective of this study was to investigate differences in circulating IL-22 levels between patients with STEMI undergoing PPCI and healthy controls; the secondary objectives were to compare serum IL-22 levels considering the culprit coronary artery, door-to-balloon time (DBT), final angiographic result, CAD classification, and presence of diabetes mellitus (DM). This evidence concerns the gene IL22 and diabetes mellitus.