Previous studies suggest that Jhih san jhen (combination of EX-HN1 [Sishencong], DU24 [Shenting], and GB13 [Benshen]) and Nie san jhen (combination of GB6 [Xuanli], GB8 [Shuaigu], and GB9 [Tianchong]) could substantially improve the development level and quality of daily life of children with intellectual disabilities, potentially due to their effects on regulating serum neuron-specific enolase and monoamine neurotransmitters [17]. Here, ENO2 is linked to Intellectual disability.