To date, several different mutations in the SYNJ1 gene have been described in several families from different countries, including Iran, Italy, India, Tunisia, Algeria, Senegal, Germany, China, and France, presenting early-onset PD, atypical parkinsonism, and JP [8,11,12,13,14,15,16], suggesting a mutational hotspot. This evidence concerns the gene SYNJ1 and Parkinsonism.