Using [68Ga]-PSMA-HBED-CC PET imaging and magnetic resonance imaging before prostatectomy and quantitative immunofluorescence microscopy for PSMA and phosphorylated Akt in prostate carcinoma patients, radioligand uptake proved most strongly correlated with Akt’s phosphorylation at S473, suggesting that PSMA-based PET imaging can serve as a predictor of the global activation status of the P13K-Akt-mTOR pathway in prostatic lesions [29]. The gene discussed is AKT1; the disease is prostate carcinoma.