More recently, Bakht et al. identified the homeobox transcription factor HOXB13, NKX3, and the forkhead box1I protein (FOXA1) as positive regulators of the PSMA-enhancer, regardless of AR-status, with knockout models pointing to HOXB13 as an upstream regulator of PSMA in both AR-positive and AR-negative prostate carcinoma [22]. The gene discussed is FOLH1; the disease is prostate carcinoma.