AKT1 and prostate carcinoma: Using gene set enrichment analysis, Kaittanis et al. demonstrated that in prostate carcinoma cells expressing PSMA (LNCaP-Ctrl and PC3-PSMA) but not in prostate carcinoma cells that lacked PSMA (LNCaP-KD and PC3-Ctrl), the levels of genes involved and regulated by Akt and mTOR were elevated and that PSMA expression increased the phosphorylation of Akt and its downstream targets S6K and 4EBP1, indicating the activity of Akt-mTOR is modulated via PSMA.