In summary, this study analyzed altered gene expression profiles in IBD patients and identified 14 key disease-related genes, including nine potential disease modulators closely linked with known IBD genes and immune-infiltrated cells (CYBB, RAC2, GNAI2, ITGA4, CYBA, NCF4, CPT1A, NCF2, and PCK1). Here, PCK1 is linked to inflammatory bowel disease.