PTPN11 and endometriosis: Hou et al. (2021) reported that the higher-level expression of regulatory T cell (Tregs)-derived soluble fibrinogen-like protein 2 (sFGL2) and its receptor CD32b may induce macrophages toward the pro-repair markers CD163 and CD206 via the SHP2-ERK1/2-STAT3 signaling pathway, which is involved in the progression of endometriosis [31].