Previous data indicate that the early subclinical DOX-induced cardiotoxicity in breast cancer patients is associated with increased expression of neutrophil-specific genes (i.e., PGLYRP1, CAMP, MMP9, CEACAM8, MPO), suggesting that neutrophils and their granular proteins are potential biomarkers for DOX-induced cardiotoxicity. The gene discussed is CEACAM8; the disease is breast carcinoma.