In this regard, in a recent study conducted by Abdel-Hamid, Mesbah, Soliman and Firgany [15], the expression of tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and IL6 were overexpressed in placentas of patients with placenta accreta; interestingly, their expression levels were associated with the number of EVT, which also were higher in comparison to normal placentation tissue samples. Here, TNF is linked to placenta accreta.