IGFBP3 and obesity due to melanocortin 4 receptor deficiency: Some other biomarkers were also investigated in children with obesity such as chemerin, which is connected to increased inflammation endothelial activation [89,90], and elevated systolic pressure [91]; catestatin, which is significantly lowered in obesity and connected to the reduction of adrenergic stimulation and regulation of oxidative stress [92]; and insulin-like growth factor binding protein-3, which is reduced in obesity and is believed to be an early marker of atherosclerosis [93].