PML and acute promyelocytic leukemia: Several recent studies have determined that H3.3K27M mutation can also disrupt the PML (Promyelocytic Leukemia) nuclear body formation, leading to a stalled differentiation, apoptosis and continuation of stem-cell-like cell proliferation phenotype, which is found to be similar to that in APL (Acute promyelocytic Leukemia) [131].