In a multivariate logistic regression model adjusted for age, sex, BMI, smoking, hypertension, hyperlipidemia, diabetes mellitus, HbA1c, creatinine, and hsCRP, the third tertiles of IL-8 and MCP-1 showed significant positive associations (OR: 2.4, p = 0.030 and OR: 2.4, p = 0.040, respectively) with the presence of pathological carotid findings compared with the first tertiles of IL-8 and MCP-1 as the reference categories. This evidence concerns the gene CXCL8 and hyperlipidemia.