Studies in patients with autoimmune diseases (e.g., psoriasis and rheumatoid arthritis), as well as in patients with type 1 diabetes mellitus and autosomal dominant polycystic kidney disease, suggest that MCP-1 may play a role in promoting vascular inflammation and atherosclerosis in these patients [39,40,41,42,43,44]. The gene discussed is CCL2; the disease is atherosclerosis.