NOTCH1 and acute lymphoblastic leukemia: Using CCL198-83 prophylactically in vitro at 5-day intervals over the course of twenty days following the induction of leukemia in the PRDM14;Mx-1-Cre mouse, in which the T-ALL cells express high levels of Notch1 mutations [21,22], we found that treatment CCL198-83 leads to an increase in the lifespan of mice that have been induced to develop T-ALL.