The participation of CD209L/L-SIGN and CD209/DC-SIGN (lung cells or macrophage-related lectins, respectively) [67] and transmembrane protein 106B (TMEM106B) [71] in S protein binding has been shown, but the lack of data concerning tissue expression changes in diabetes affects the ability to discuss their possible functions in the development of diabetes-induced severe COVID-19. Here, TMEM106B is linked to diabetes mellitus.