ACE2 and infection: It could suggest a lower abundance of membrane-bound ACE2 (in the context of the proposed SIT1 mechanism of action) and a lower susceptibility of respiratory track cells to SARS-CoV-2 infection, unless other unrecognised mechanisms of SARS-CoV-2 cell uptake upregulated by the gene’s increased expression dominate over the ACE-2-dependent way of infection in alveolar cells or some other factors are engaged.