ASGR1 and Niemann-Pick disease: On the other hand, asialoglycoprotein receptor 1 (ASGR1), Niemann–Pick disease, type C1 (NPC1), and AXL, as well as co-receptors of ACE2, such as heparan sulphate and scavenger receptor, class B type 1 (SR-B1), are downregulated in diabetes [63,66,73,86,91].