Molecular docking of the active compound 4c with the EGFR (PDB ID: 6DUK) and MetAP2 (PDB ID: 5D6E) proteins, which are potential targets in esophageal cancer, revealed hydrogen bonding interactions between the functional groups of the compound, including the furan ring and carbonyl groups, with specific amino acid residues. This evidence concerns the gene METAP2 and esophageal cancer.