Nevertheless, one report has revealed that platelet activating factor receptor (PTAFR), which is significantly upregulated in the brain tissue, peripheral blood, and CSF of AD patients, may be a potential AD biomarker; notably, PTAFR triggers the inflammatory responses mediated by microglia through the interleukin (IL)-10/STAT3 pathway [58]. This evidence concerns the gene PTAFR and Alzheimer disease.