CDK6 and ischemia: Another more recent work reported that remote ischemic pre-conditioning (RIPC) exerts protective effects against brain injury resulted from ischemia/reperfusion; interestingly, the salutary effects of RIPC involve downregulation of the STAT3 pathway, with resultant inhibition of neuronal CCR by inhibiting cyclin D1 and CDK6 triggered by transient focal ischemia [55].