Genistein exhibits its activity through two approaches: firstly, the chemoprevention by inhibiting the formation of COX-2 and oxidative stress; secondly, by targeting carcinogenesis possible pathways and interfering with their mechanism via suppressing cancer cell proliferation, metastasis, invasion, tumor angiogenesis, regulation of epigenetic, activation of survival pathway, matrix metalloproteinase (MMP), and vascular endothelial growth factor (VEGF) [98]. This evidence concerns the gene PTGS2 and cancer.