Strikingly, in our cohort, there was a pronounced inverse correlation between FLT3 mutations and ETV6-RUNX1, suggesting a mutually exclusive relationship between FLT3 mutation and ETV6-RUNX1 in ALL tumorigenesis, which may be attributed to the propensity of mutated patients to lack the fusion gene [27]. This evidence concerns the gene RUNX1 and acute lymphoblastic leukemia.