Gui et al. aimed to examine the associations of cardiovascular risk factors (e.g., current smoking and alcohol consumption, physical inactivity, obesity, total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol, diabetes, and hypertension) and variants of APOE and translocase of outer mitochondrial membrane 40 (TOMM40) with global cognitive function through the use of the Mini Mental State Examination (MMSE) score in elderly individuals [12]. Here, APOE is linked to obesity due to melanocortin 4 receptor deficiency.