PTGS2 and cancer: A previous study showed that BNE-RRC inhibits cancer cell growth through various mechanisms, including the suppression of inflammatory proteins, like COX2; the regulation of the cancer development regulation protein β-catenin; the inhibition of the cancer cell survival protein AKT; the downregulation of the anti-apoptotic protein GRP78; and the reduction in the invasion-associated protein MMP9 [36].