Also, miR-23b (from the same cluster) has been shown to regulate the expression of μ-opioid receptors [106] and to be underexpressed in various autoimmune diseases via suppressing interleukin 17 (IL-17), tumor necrosis factor α (TNF- α), or IL-1β-induced NF-kB activation [107]. Here, IL1B is linked to autoimmune disease.