A study has shown that gastrodin could increase the content of 5-hydroxytryptamine (5-HT) in the brain tissue of p-chlorophenylalanine (PCPA)-treated mice with insomnia and regulate the expression of interleukin-6 (IL-6), interleukin-1beta (IL-1β), B-cell lymphoma-2 (BCL-2) protein and the p-extracellular regulated protein kinases (p-ERK)/ERK ratio in the brain, improving the sleep condition of PCPA mice [40]. This evidence concerns the gene IL6 and insomnia measurement.