Another study also showed that the expression levels of glutamate, p-ERK1/2, p-mitogen-activated extracellular signal-regulated kinase (MEK)1/2 and BDNF in the striatal neurons of streptozotocin-induced DM rats were regulated by gastrodin, which effectively alleviated neurotoxicity in neurons and significantly improved the degeneration of striatal neurons [76]. The gene discussed is BDNF; the disease is diabetes mellitus.