It has been shown that gastrodin increased levels of heme oxygenase 1 (HO-1), superoxide dismutase (SOD), glutathione (GSH) and nuclear translocation of Nrf2 in the striatum of mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD. Here, HMOX1 is linked to Parkinson disease.