MPO and Parkinson disease: In addition, gastrodin can reduce the activity of substantia nigra pars compacta (SNc) myeloperoxidase (MPO) in rats with 6-hydroxydopamine (6-OHDA)-induced PD, reduce the levels of lipid peroxidation and the production of nitric oxide (NO) and improve the catalepsy and motor incoordination induced by 6-OHDA [88].