Elevated systolic and diastolic BP values in the LDLR-KO mice were attenuated by knocking out the CB1R. HFD-induced vascular remodeling effects can predispose individuals to hypertension and other cardiovascular diseases, which can be partially prevented in the absence of CB1Rs. These results suggest novel therapeutic pathways for improving vascular functions in AS and its accompanying comorbidities. The gene discussed is LDLR; the disease is cardiovascular disorder.