LDLR-KO mice kept on a high-fat diet (HFD) are relevant mouse models for the human familial hypercholesterolemia and are commonly used in animal experiments investigating hyperlipidemia and AS; these mice develop cholesterol levels as high as 800–1000 mg/dL when kept on a long-term HFD [7,11,12,13,14]. This evidence concerns the gene LDLR and familial hypercholesterolemia.