However, in LDLR−/− groups, the HFD induced a pronounced elevation of the plasma cholesterol concentrations, far into the level of pathological hypercholesterolemia compared to the CD (p = 0.001 between CB1R−/−, LDLR−/−, HFD mice and CB1R−/−, LDLR−/−, CD mice; p = 0.006 between CB1R+/+, LDLR−/−, HFD mice and CB1R+/+, LDLR−/−, CD mice). Here, CNR1 is linked to familial hypercholesterolemia.