Elevated systolic and diastolic BP values in the LDLR-KO mice were attenuated by knocking out the CB1R. HFD-induced vascular remodeling effects can predispose individuals to hypertension and other cardiovascular diseases, which can be partially prevented in the absence of CB1Rs. These results suggest novel therapeutic pathways for improving vascular functions in AS and its accompanying comorbidities. This evidence concerns the gene CNR1 and hypertensive disorder.