The results of our research also have diagnostic (search for potential molecular biomarkers of inflammation/disease) and therapeutic potential (modulation of miR-dependent pathways, e.g., NF-ĸB and NLRP3 inflammasome) in the course of acute liver failure (ALF) and organ dysfunction in multi-organ failure (MOF) of a viral etiology that we encounter during Lagovirus europaeus infection. This evidence concerns the gene NLRP3 and acute liver failure.