SIRT7 and cardiac hypertrophy: Cardiac-specific conditional knockout Sirt7 in mice exacerbates TAC-induced cardiac hypertrophy and fibrosis, whereas NMN treatment attenuates phenylephrine-induced cardiac hypertrophy, but the change is abolished by Sirt7 knockdown, suggesting that NMN mediates cardiac hypertrophy in a Sirt7-dependent manner [61].