With respect to changes in PPT values with reduced SIK1 levels, once more, the FM subgroup not fulfilling ME/CFS diagnosis criteria seems to behave as the complete FM group, indicating that 50% of patients in the group (FM with ME/CFS diagnosis) were mostly irresponsive to MT, at least symptom wise with SIK1 changes. This evidence concerns the gene SIK1 and myalgic encephalomeyelitis/chronic fatigue syndrome.