In mammals, FOXO3 plays a role in stress resistance, cell proliferation/arrest, survival/death, metabolism, and autophagy; moreover, FOXO3 is involved in tumor suppression, regulation of energy metabolism, development of specific tissues, genomic integrity preservation, and a reduction of oncogenic mutation accumulation [6,25,26,27,28,29,30,31]. This evidence concerns the gene FOXO3 and neoplasm.