Both ML49.3 mAb and EBP2 hFab recognize mScg3 and hScg3, block hScg3-induced proliferation of endothelial cell in vitro and alleviate pathological angiogenesis and vascular leakage in mouse models of DR, CNV and ROP [15,16,17,18,21,23,24]. Here, MRPL49 is linked to retinopathy of prematurity.