MiR-144-3p targets ARIDIA, miR-141 targets ZEB2, and miR-130b and miR-96-5p target PTEN; all promote sunitinib resistance in RCC by over- or under-expression, thus regulating tumor suppressors and oncogenes to promote tumor proliferation [55,58,59,60,61]. The gene discussed is PTEN; the disease is neoplasm.