PLEC and epidermolysis bullosa simplex: Figure 1 represents the characteristics of these different subtypes. Rare subtypes of EBS exist, for which other causal mutations were identified in several genes (plectin (PLEC), Kelch-like member 24 (KLHL24), dystonin (DST), exophilin-5 (EXPH5), and CD151 molecule (CD151)) [11,12].