We decided to pursue the following characterization experiments with the GBA1-HiBiT line only for the following reasons: (i) these cells presented a significant increase in luminescence (Figure 3E); (ii) the function of GBA1 is already well known; (iii) drugs are commercially available and known to increase GCase activity, which improves lysosomal function and prevents α-syn aggregation; (iv) GBA1 represents the most common genetic risk factor for PD. Here, GBA1 is linked to Parkinson disease.