Conversely, miR-15b and miR-141 exert anti-antifibrotic effects by targeting TGFβR1 and TGF-β1, respectively, thus preventing the activation of the fibrotic signaling pathway; miR-15b and miR-141 have been shown to be downregulated by hyperglycemia, with the consequent upregulation of TGFβR1 and TGF-β1. The gene discussed is TGFB1; the disease is Hyperglycemia.