TLR4 and Alzheimer disease: When we looked at central suppressors or mediators of AD-related neuroinflammation, including tumor necrosis factor alpha (Tnfa), interleukin-18 (Il18), interleukin-1 receptor-associated kinase-1 (Irak1), the C-C motif chemokine receptor 7 (Ccr7), suppressor of cytokine signaling factor 1 (Socs1), and Tlr4, no significant differences were found in terms of genotype, age, or brain region in 5xFAD mice by three-way ANOVA (Supplementary Table S1).