APP and Alzheimer disease: One of the most widely used amyloid-based models is the 5xFAD mouse [19], which exhibits overexpression of APP and PSEN1 containing five familial AD mutations: [APP K670N/M671L (Swedish), APP I716V (Florida), APP V717I (London), as well as the PSEN1 M146L and the PSEN1 L286V] [20,21].