CDKN1A and colorectal carcinoma: As for the premature senescence (induced by various factors such as DNA damage [654], oxidative stress [655], and certain drugs [656]), it seems that the deficiency of Caveolin-1, a protein involved in various cellular processes, could be a key factor in CRC cell death through activation of the TP53-p21 pathway, a well-known regulator of cell cycle progression and senescence [657].