SMAD4 and colorectal carcinoma: These tests have revealed a range of mutations in CRC, including in genes such as APC, MLH1, MSH2, MSH6, PMS2, MUTYH, NTHL1, KRAS, TP53, FBXW7, PIK3CA, BRAF, CTNNB1, ERBB2, and SMAD4 [1621,1622,1623].