This reprograms macrophages towards a pro-inflammatory M2-like state characterized through different axis like miR-21-5p promoting TLR-7/IL-6 and miR-25-3p, miR-130b-3p, and miR-425-5p targeting PTEN/PI3K/AKT, which in turn enhances EMT and metastasis of CRC cells [1264,1265,1266,1267]. The gene discussed is IL6; the disease is colorectal carcinoma.