In addition to the key driver mutations mentioned above, CRC can also harbor various other genetic alterations in genes regulating DNA repair (i.e., POLE, POLD1) [224], chromatin remodeling (i.e., ARID1A) [225], and cell cycle regulation (i.e., PIK3CA, SMAD4) [226]. The gene discussed is PIK3CA; the disease is colorectal carcinoma.