Beyond the TGF-β and Wnt/β-catenin pathways, other signaling cascades such as Hedgehog (Shh), Notch, hypoxia-inducible factors, and receptor tyrosine kinases converge on EMT transcriptional programming to fully induce the migration and invasion phenotypes crucial for CRC metastatic dissemination [1294]. The gene discussed is TGFB1; the disease is colorectal carcinoma.