Interestingly, cancer cells under hypoxia could express higher mRNA levels of chemokines, including chemokine C-X-C motif ligand 1 (CXCL1)/keratinocyte-derived chemokine (KC), chemokine C-X-C motif ligand 2 (CXCL2)/macrophage inflammatory protein-2 (MIP2) and chemokine C-X-C motif ligand 2 (CXCL5)/Lipopolysaccharide-induced CXC Chemokine (LIX), which are supposed to be released to the surroundings of cancer cells to attract neutrophils [156]. The gene discussed is CALCA; the disease is cancer.