Still, in malignant disease, TGF-β promotes immune escape, tumor progression, and extramedullary spread [149,157,158,159,160] through various mechanisms, such as release of soluble NKG2Ls via proteolytic cleavage or exosomal release of membrane-bound NKG2DL [161,162,163,164,165]. The gene discussed is TGFB1; the disease is neoplasm.