The CXCL12/CXCR4 pathway is involved in several aspects of tumor pathogenesis [4], promoting tumor vasculogenesis and angiogenesis in tumor stem-like glioma cells [5] or regulating lymphoid tumor microenvironment in diffuse large B-cell lymphoma (DLBCL) [6]. Here, CXCR4 is linked to diffuse large B-cell lymphoma.