The effects of anti-infective treatment (scaling and root planning) in 13 periodontitis patients were monitored by aMMP-8, the rate of aMMP-8 RFU activity, tMMP-8, MPO, PMN elastase, TIMP-1, calprotectin, and IL-6 as well as by clinical periodontal parameters (Figure 2 and Figure 3). The gene discussed is TIMP1; the disease is periodontitis.