Additionally, miR-3154 functions as an oncomiR, is elevated in both HCC and liver cancer stem cells, and plays a significant role in HCC progression by targeting HNF4α and promoting self-renewal, proliferation, metastasis, and tumorigenesis [399].Increased miR-3154 expression was observed in lenvatinib-resistant HCC cell lines, and lenvatinib sensitivity was improved following miR-3154 knockdown. The gene discussed is HNF4A; the disease is hepatocellular carcinoma.