Key pathways involved in HCC pathogenesis, including the receptor tyrosine kinase (RTK), fibroblast growth factor (FGF), PI3K/Akt and MAPK/ERK, WNT, Hedgehog, Notch, JAK/STAT, and ubiquitin-proteasome pathways, are dysregulated in liver cancer due to genetic and epigenetic factors [9]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.