The stemness characteristics of cancer cells are maintained through various signaling pathways including Wnt/β-catenin, IL-6/STAT3, TGF-β, Notch, HH, Hippo, BMI1, NF-κB, PI3K/Akt/mTOR, and Ras/Raf/MAPK [152]. This evidence concerns the gene AKT1 and cancer.