NFKB1 and hepatocellular carcinoma: Specifically, researchers found that in the metastatic lung niche, HCC cells secrete exosomal miR-1247-3p, which leads to the conversion of normal fibroblasts into CAFs through direct inhibition of B4GALT3 and activation of β1-integrin/NF-κB signaling in fibroblasts [263].