TGFB1 and cancer: Dysregulation of miRNAs in HCC can affect key signaling pathways including TGF-β/Smad, MAPK, NF-kB, JAK/STAT, Hedgehog, Wnt/β-catenin, and Hippo-YAP transcriptional co-activators with TAZ, which are involved in EMT induction, and cancer progression (Figure 4) [171,172].