The search strategy was based on specific MeSH terms, including adipocytes, adipose tissue, adipokines, leptin, adiponectin, resistin, obesity, kisspeptins, inflammation, hypothalamus, pituitary gland, ovary, reproduction, fertility and polycystic ovary syndrome, which were used alone or in combination. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.