In ALS, caused by FUS (Fused in Sarcoma) mutations, the enrichment of FUS-NUP62 C-ter interactions in the cytoplasm has been reported to promote their co-phase separation into amorphous assemblies [54], thus interfering with the localization of NUP62 to the NPC, resulting in NTC defects. This evidence concerns the gene NUP62 and amyotrophic lateral sclerosis.